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  • Cosequin® for Dogs
  • Cosequin® for Cats
  • Cosequin® Equine

Cosequin is a patented, scientifically researched nutritional supplement dispensed by thousands of veterinarians to help dogs maintain healthy joints. As dogs age, it is common for their joints to become less flexible which impacts their mobility and quality of life. You may have noticed that your dog has difficulty walking up stairs or jumping on the bed. While he used to be eager to play, now he is content to rest. Even at younger ages some dogs are subject to joint health concerns which affect flexibility and mobility. Cosequin contains TRH122®* chondroitin sulfate, FCHG49®* glucosamine and manganese ascorbate. These ingredients have been scientifically formulated to support and maintain the health of your dog's joints. Published studies have shown that the specific combination of ingredients in Cosequin works together to maintain the structure of the cartilage in your dog's joints while inhibiting the enzymes that break down cartilage. It is very important to note that the published studies on Cosequin do not apply to other brands.

Cartilage is a slippery and resilient tissue produced and maintained by its own specialized cells. It cushions the surfaces where two or more bones meet to form a flexible joint. When a dog is in motion there is tremendous pressure on the joint. Cartilage, joint fluid, and underlying bone work together like a shock absorber allowing flexible joint function. Because cartilage lacks a direct blood supply, nutrients must pass into the cartilage from surrounding tissue. These nutrients sustain cartilage cells and provide the components necessary to maintain a healthy cartilage structure. Scientists are not sure about all the factors that cause cartilage breakdown; however, they have discovered enzymes that play a role in the process. With age, injury, or over-activity, the process of breakdown can exceed the process of replacement leading to problems in the joints. These problems result in less flexibility. That’s when it's time for Cosequin® which maintains the cartilage structure and inhibits the enzymes that break down cartilage.

The exclusive combination of TRH122® chondroitin sulfate, FCHG49® glucosamine, and manganese ascorbate in Cosequin works together to maintain the structure of your dog's joint cartilage while slowing the enzymes that break down cartilage. Glucosamine hydrochloride acts as a building block of cartilage by supplying a key nutrient that keeps cartilage cells healthy and functioning properly. Chondroitin sulfate blocks the enzymes thatbreak down cartilage. Manganese ascorbate is added to help optimize the production of cartilage components. Cosequin has been used since 1992 in animals to maintain joint health. While the ingredients have been used separately, published controlled studies show the patented combination of ingredients in Cosequin is superior to using the ingredients alone.

Yes. On the label, different brands may appear to be the same, but unlike drugs, the ingredients in supplements are not equivalent. Cosequin, with its exclusive combination of high purity glucosamine, low molecular weight chondroitin sulfate and manganese ascorbate, is the only glucosamine/chondroitin sulfate supplement that has been shown safe, effective, and bioavailable in peer-reviewed, published, controlled, U.S. veterinary studies. Chondroitin sulfate is a large molecule that is difficult to absorb. Low molecular weight means the particle size of the molecule is smaller and more easily absorbed by the digestive system than other less pure forms of chondroitin sulfate. While the low molecular weight chondroitin sulfate is more expensive, it is supported by published, controlled U.S. clinical studies for efficacy, safety and absorption. Cosequin is manufactured in the United States by Nutramax Laboratories Veterinary Sciences, Inc. following manufacturing standards adopted by the pharmaceutical industry. Each batch of Cosequin is subjected to stringent quality control measures and meets label claim. However, a number of reports including a study published in the Journal of the American Nutraceutical Association showed that up to approximately 80% of glucosamine/chondroitin sulfate brands did not meet their own label claim.

Yes. None of the foods contain the researched combination of high quality ingredients in Cosequin. The amount of glucosamine and chondroitin sulfate in dog food is often minimal. Even if these diets contained high quality glucosamine and chondroitin sulfate, a large-breed dog would need to consume more than the daily requirement of food to obtain the amounts of glucosamine and chondroitin sulfate found in Cosequin DS. In addition, both glucosamine and chondroitin sulfate may degrade when subjected to the heat or extreme pressure in the manufacturing process of commercial dog food.

Many human glucosamine/chondroitin sulfate supplements use substandard ingredients, and, as noted earlier, studies have shown that many do not even meet their own label claim for the ingredients listed on the bottle. With Cosequin each capsule or convenient tasty chewable tablet contains exactly what is stated on the label. These trademarked ingredients have been shown to be safe and effective in pets.

Early action is always the best advice. Different breeds of dogs age at different rates. With regular check-ups your veterinarian can talk with you about your dog’s aging process. Your veterinarian may discuss weight control, selective use of medications, exercise and the administration of Cosequin. It is important to have your dog examined by your veterinarian if you notice the dog having difficulties climbing stairs, jumping into the car, going for walks or even getting up. Your veterinarian can advise you if Cosequin can help. Your veterinarian may also suggest using Cosequin as a protective measure. This can be important for maintaining an active life for many dogs, especially large breeds and working dogs of all sizes. Cosequin may also be used to help support cartilage following joint surgery.

Observe your dog closely, and notice whether he seems more comfortable performing everyday activities such as climbing up stairs, going for walks, or even getting up. Most people will observe gradual changes in their dog’s comfort level. In a published survey of over 3,000 veterinarians, over 80% of dogs administered Cosequin improved significantly in their mobility, level of comfort, and attitude. Overall, the veterinarians rated Cosequin as good to excellent.

Since Cosequin is a supplement and provides nutrients to maintain your dog’s joint health, it works more gradually than drugs. Improvement on Cosequin can range from gradual to dramatic. Following the administration schedule on the label for your dog’s weight, we recommend an initial administration period of four to six weeks. Some dogs may show a response in a shorter period of time.

Research in dogs administered Cosequin has shown that if Cosequin is given prior to an injury, the animal returns to normal function much more quickly. In light of this research, Cosequin is recommended to protect cartilage in dogs that are overweight, working breeds, and large breeds, as well as the average "weekend warrior". In order to gain the protective benefits of Cosequin in healthy animals, a low level of Cosequin may be used. The level for these pets varies, but the suggested maintenance level given every other day may be adequate.

Cosequin offers unparalleled safety. A safety study in dogs demonstrated no adverse effects of Cosequin administration on blood work parameters, including complete blood count, biochemical, and clotting values. Some dogs may experience a mild gastrointestinal upset such as that which occurs when switching foods. If this is the case, you can try offering Cosequin with a meal.

Exercise is important for optimal joint function as well as weight control for the overall health of your pet. Joint movement is needed to circulate fluid around the cartilage as well as to bring nutrients and to remove waste products. It has been shown that when joints are immobilized, cartilage structures break down at a rapid rate. Consult with your veterinarian, but in most cases, moderate exercise is recommended. Walking on sand or another soft surface or even swimming will help circulate needed nutrients and reduce excessive stress to the cartilage. It is important not to push your pet but to exercise at a comfortable pace.


Cosequin is a patented, scientifically researched nutritional supplement dispensed by thousands of veterinarians to help cats maintain healthy joints. As cats age, it is common for their joints to become less flexible which impacts their mobility and quality of life. You may have noticed that your cat is less eager to jump to her favorite spot. While she used to prowl and chase “prey”, now she is content to rest. Cosequin contains TRH122®* low molecular weight chondroitin sulfate, FCHG49®* glucosamine hydrochloride and manganese ascorbate. These ingredients have been scientifically formulated to support and maintain the health of your cat's joints. Published clinical studies have shown that the specific combination of ingredients in Cosequin works together to maintain the structure of the cartilage in the joints while inhibiting the enzymes that break down cartilage. It is very important to note that the published clinical studies on Cosequin do not apply to other brands.

Cartilage is a slippery and resilient tissue produced and maintained by its own specialized cells. It cushions the surfaces where two or more bones meet to form a flexible joint. Cartilage, joint fluid, and underlying bone work together like a shock absorber allowing flexible joint function. Because cartilage lacks a direct blood supply, nutrients must pass into the cartilage from surrounding tissue. These nutrients sustain cartilage cells and provide the components necessary to maintain a healthy cartilage structure. Scientists are not sure about all the factors that cause cartilage breakdown; however, they have discovered enzymes that play a role in the process. With age, injury, or over-activity, this process of breakdown can exceed the process of replacement leading to problems in the joints. These problems result in less flexibility. That’s when it’s time for Cosequin which maintains the cartilage structure and inhibits the enzymes that break down cartilage.

The exclusive combination of TRH122® chondroitin sulfate, FCHG49® glucosamine, and manganese ascorbate in Cosequin works together to maintain the structure of your cat's joint cartilage while slowing the enzymes that break down cartilage. Glucosamine hydrochloride acts as a building block of cartilage by supplying a key nutrient that keeps cartilage cells healthy and functioning properly. Chondroitin sulfate blocks the enzymes thatbreak down cartilage. Manganese ascorbate is added to help optimize the production of cartilage components. Cosequin has been used since 1992 in animals to maintain joint health. While the ingredients have been used separately, published controlled studies show the patented combination of ingredients in Cosequin is superior to using the ingredients alone.

There are not many joint support options available specifically for cats. There are some products used in dogs that are not as safe in cats. Cosequin has been shown to be safe in cats. Cosequin, a nutritional supplement, safely and effectively provides joint cartilage support while maintaining your cat's comfort level.

Early action is always the best advice. With regular checkups your veterinarian can talk with you about your cat's aging process. Your veterinarian may discuss weight control and the administration of Cosequin to help your cat in her senior years. Whenever you notice limping, stiffness, or a reluctance to jump, it is important to have your cat examined by your veterinarian. Your veterinarian can advise you if Cosequin can help. Joint problems generally get worse with time. When your veterinarian recommends Cosequin, the sooner it is started, the more opportunity your pet will have to respond and return to normal activity.

Some veterinarians also recommend Cosequin to help support urinary bladder health. The inner lining of the bladder wall is protected by a layer, which contains some of the same compounds as are found in cartilage. This layer prevents urine and the waste products contained within it from seeping into and damaging the lining. Since the low molecular weight chondroitin sulfate found in Cosequin is available to more than just cartilage cells, the bladder may use it to help support this protective layer.

Since Cosequin is a supplement and provides nutrients to maintain your cat’s health, it works more gradually than drugs. Improvement using Cosequin can range from gradual to dramatic. Following the administration schedule on the label, we recommend an initial administration period of 4-6 weeks. Some cats may show an optimal response in a shorter period of time. The long-term maintenance level is one capsule every other day. Administration may be increased at any time depending on your cat's needs.

Yes. Cosequin, with its exclusive combination of high purity glucosamine, low molecular weight chondroitin sulfate and manganese ascorbate, is the only glucosamine/chondroitin sulfate supplement that has been shown safe, effective, and bioavailable in peer-reviewed, published, controlled, U.S. veterinary studies. Chondroitin sulfate is a large molecule that is difficult to absorb. Cosequin is the only brand that uses the high purity, TRH122® low molecular weight chondroitin sulfate that has been studied for absorption. Lower molecular weight means the particle size of the molecule is smaller and more easily absorbed by the digestive system than other less pure forms of chondroitin sulfate. While this highly pure form of chondroitin sulfate is more expensive, it is the only one supported by published, controlled U.S. clinical studies for efficacy, safety and absorption. Cosequin is manufactured in the United States by Nutramax Laboratories Veterinary Sciences, Inc. following manufacturing standards adopted by the pharmaceuical industry. Each batch of Cosequin is subjected to stringent quality control measures and meets label claim, while a study published in the Journal of the American Nutraceutical Association showed that over 80% of glucosamine/chondroitin sulfate brands did not meet their own label claim.

Supplements that contain perna mussel (or greenlipped mussel) have not been subjected to the same type of research as Cosequin. There is no published evidence that the nutrients in perna mussel products have the same capacity to maintain the health of cartilage while protecting it from destructive enzymes. A consumer should be cautioned about buying a product unless the specific brand has been subjected to published, controlled, peer-reviewed clinical studies.

Cosequin offers unparalleled safety. A safety study in cats demonstrated no adverse effects of Cosequin administration on blood work parameters, including complete blood count, biochemical and clotting values. Some cats may experience a mild gastrointestinal upset such as may occur when switching foods, but this usually will resolve itself.

Cosequin Capsules for Cats contain a flavored powder. The capsule can be opened and contents mixed with or sprinkled over the food. The capsule may instead be “pilled” if more convenient.


Cosequin ASU from Nutramax Laboratories Veterinary Sciences, Inc. is a superior joint health supplement in a tasty powder for horses that goes beyond standard joint supplements. It contains NMX1000®* avocado/soybean unsaponifiables (ASU), MSM (methylsulfonylmethane), FCHG49®* glucosamine hydrochloride, and TRH122®* low molecular weight chondroitin sulfate. With this combination of active ingredients, Cosequin ASU is the most complete joint support supplement available for horses.

The combination of the trademarked FCHG49 glucosamine hydrochloride and TRH122 low molecular weight chondroitin sulfate supports cartilage production and inhibits joint enzymes that break down cartilage.These two ingredients together have been shown to protect joint cartilage better than either ingredient alone. A greater than additive effect, known as a “synergistic” effect, on cartilage cells was seen using Nutramax Laboratories Veterinary Sciences, Inc. specific glucosamine and low molecular weight chondroitin sulfate together.

ASU stands for avocado/soybean unsaponifiables, derived from avocados and soybeans. Studies using cartilage cells have shown that it lowers the expression or production of several compounds involved in the process of cartilage breakdown in joints. ASU complements the positive effects of the glucosamine and chondroitin sulfate in Cosequin ASU. The glucosamine in Cosequin ASU is synergistic with low molecular weight chondroitin sulfate and has been shown in cartilage cell studies to be synergistic with ASU. Having ASU in the Cosequin ASU formula is especially beneficial as NMX1000® avocado/soybean unsaponifiables, FCHG49® glucosamine hydrochloride and TRH122® low molecular weight chondroitin sulfate together were shown in cell studies to be more effective than the combination of glucosamine and chondroitin sulfate alone at inhibiting expression of several agents involved in the breakdown of cartilage.

Although clinical data on MSM is limited, many veterinarians and trainers recommend the use of MSM in the management of joint health. MSM is an organic source of sulfur, a compound used by cartilage. MSM with ASU, glucosamine hydrochloride, and chondroitin sulfate provides a joint health supplement formula for those individuals that would like to additionally supplement with high purity MSM.

Broad spectrum means that the ingredients support cartilage health via many pathways. As mentioned earlier, the ingredients inhibit compounds and enzymes in the joint that contribute to cartilage breakdown while also supporting cartilage production.

Cosequin ASU contains the ingredient ASU along with the optimal amounts of glucosamine and chondroitin sulfate that your horse needs. ASU works along with glucosamine and chondroitin sulfate to support your horse's joints. In fact, the combination of glucosamine/chondroitin sulfate plus ASU has been shown to work better in cartilage cell studies than the combination of glucosamine/chondroitin sulfate alone. Cosequin ASU has the further addition of high purity MSM. Some veterinarians suggest using MSM to help manage joint health.

Cosequin ASU has been evaluated in a safety study in horses, and no adverse effects were noted from administration. There are no known contraindications or known interactions between Cosequin ASU and any drug or nutritional supplement.

No studies have been completed that specifically address the use of Cosequin ASU during pregnancy. Use of Cosequin ASU during pregnancy should be an individual decision made in consultation with your veterinarian.

Cosequin ASU contains supplement ingredients for assisting joint health. It is best to check with your appropriate authority regarding its regulations or restrictions on supplement usage.

Prior to starting Cosequin ASU, you may have noticed unevenness of gait, reluctance to take or change a lead, or shortness of stride, which may be early indicators of cartilage breakdown. After starting administration with Cosequin ASU, observe your horse closely, and notice whether your horse becomes more comfortable doing those activities he/she seemed reluctant doing or had some trouble doing previously. Changes in your horse’s comfort level may occur gradually. Please allow time for your horse to respond. As noted above, it may take 2-4 weeks to see improvement, though some horses may respond sooner.

Cosequin ASU helps to minimize ongoing joint wear and tear by supporting joint cartilage production and by inhibiting enzymes and mediators involved in cartilage breakdown. Horses will usually respond to Cosequin ASU within 2-4 weeks, sooner in some horses. In some cases in which a more immediate response is desired, your veterinarian may initially recommend an injectable product.


Nutramax Laboratories Veterinary Sciences Inc. Logo

946 Quality Drive, Lancaster, SC 29720 * Toll free: 888-886-6442 * Local: 803-289-6000

Nutramax Laboratories Veterinary Sciences Inc. Logo

946 Quality Drive, Lancaster, SC 29720 * Toll free: 888-886-6442 * Local: 803-289-6000